Meenakshi Seshadri was born as Shashikala Seshadri on 16 November 1963 in Sindri, Bihar, India, an area now in Jharkhand. She was trained in several Indian classical dance forms, including Bharatanatyam, Kathak, Kuchipudi and Odissi.
At the age of 17, she won the Eve's Weekly Miss India title in 1981. Her success in the beauty pageant helped open the way for her career in the Hindi film industry.
She made her film debut with Painter Babu (1983), but her major breakthrough came soon afterward with Hero (1983), directed by Subhash Ghai and co-starring Jackie Shroff. The film became a major success and established Meenakshi as a leading actress.
During the 1980s, she appeared in numerous successful and acclaimed films, including Meri Jung (1985), Swati (1986), Dacait (1987), Shahenshah (1988), Awaargi (1990), Jurm (1990), and Ghayal (1990). Her performances demonstrated her versatility across romance, drama, action and socially relevant cinema.
One of her most acclaimed performances came in Damini (1993), directed by Rajkumar Santoshi. Her portrayal of Damini, a woman who fights for justice despite powerful opposition, became one of the defining performances of her career. The film remains particularly associated with Meenakshi's strong dramatic performance.
Other notable films from her career include Ghar Ho To Aisa (1990), Aaj Ka Goonda Raj (1992), Kshatriya (1993), Sadhna (1993), Duet (1994), Ghatak: Lethal (1996), and Swami Vivekananda (1998). She also worked in Tamil and Telugu cinema.
After the late 1990s, Meenakshi largely withdrew from the film industry. She married Harish Mysore, an investment banker, in 1995 and eventually settled in Texas, United States. She has two children. She has also devoted herself to classical dance and has taught dance in the United States.